What is ethanolamine (CAS 141-43-5)?
Ethanolamine, also known as monoethanolamine (MEA) or 2-aminoethanol, is a versatile organic compound that plays a role in the pharmaceutical and life sciences industry. Its unique chemical structure-containing both a hydroxyl (-OH) and an amino (-NH₂) group-makes it both a weak base and a reactive intermediate, widely used in drug formulation and synthesis.
In pharmaceutical formulations, MEA is used primarily for buffering or preparation of emulsions. MEA can be used as pH regulator in cosmetics. It is an injectable sclerosant as a treatment option of symptomatic hemorrhoids.
What is ethanolamine (CAS 141-43-5) used for in pharmaceuticals?
As a pH Regulator / Buffering Agent
Ethanolamine is commonly used in pharmaceutical formulations as a pH adjuster or buffering agent, particularly in:
- Topical creams and gels
- Injectable drug solutions
- Ophthalmic and nasal formulations
Intermediate in Active Pharmaceutical Ingredient (API) Synthesis
Ethanolamine is a building block in the synthesis of APIs, especially for:
- Antihistamines (e.g. diphenhydramine)
- Local anesthetics
- Beta blockers
- CNS drugs
Salt Formation Agent
In many drugs, ethanolamine is used to form ethanolamine salts of acidic drugs (e.g. NSAIDs, certain antibiotics), which:
- Enhance water solubility
- Improve oral absorption
- Modify drug release profiles
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