Breast cancer (BC) is the most frequent cancer among women worldwide and is the leading cause of cancer-related deaths in women. Cancer cells with stem cell-like features and tumor-initiating potential contribute to drug resistance, tumor recurrence, and metastasis. To achieve better clinical outcomes, it is crucial to eradicate both bulk BC and breast cancer stem cells (BCSCs). Salinomycin, a monocarboxylic polyether antibiotic isolated from Streptomyces albus, can precisely kill cancer stem cells (CSCs), particularly BCSCs, by various mechanisms, including apoptosis, autophagy, and necrosis. There is increasing evidence that salinomycin can inhibit cell proliferation, invasion, and migration in BC and reverse the immune-inhibitory microenvironment to prevent tumor growth and metastasis. Therefore, salinomycin is a promising therapeutic drug for BC. This review summarizes established mechanisms by which salinomycin protects against BC and discusses its future clinical applications.
Salinomycin is a polyether antibiotic isolated from the Streptomyces albus strain that participates in the transportation of K+ ions through cell membranes, eventually leading to increased intracellular Ca2+ concentration. From: pH-Interfering Agents as Chemosensitizers in Cancer Therapy, 2021.
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Gnee Chem was founded in March 2014.
The company specializes in the international trade industry and has set its sights on becoming an international supply chain.
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