865-47-4
What is potassium tert-butoxide (KOtBu)?
Potassium Tert-butoxide (KOtBu) is an organic compound with the molecular formula of c4h9ok. It is an important organic base. The alkalinity is greater than that of potassium hydroxide. Due to the induction effect of (CH3) 3Co trimethyl, it has stronger alkalinity and activity than other alcohol potassium, so it is a good catalyst.
| Purity | ≥99% |
| CAS NO | 865-47-4 |
| EINECS No. | 212-740-3 |
| Appearance | White powder crystal |
| Density | 0.910 g/cm³ |
| melting point | 256-258 ºC (dec.)(lit.) |
| Boiling Point | 275ºC |
| Free base (NaOH)% | ≤1.5 |
| Molecular Formula | C4H9OK |
| Application | Used in the organic synthesis |
What is the use of potassium tert-butoxide?
Potassium tert-butoxide (CAS 865-47-4) is an effective reagent in organic synthesis, pharmaceutical manufacture, and chemical research. Its high basicity and non-nucleophilic characteristics make it essential in many chemical processes.
Potassium tert-butoxide (CAS 865-47-4) is widely used in organic synthesis such as chemical industry, medicine and pesticide, such as transesterification, condensation, rearrangement, polymerization, ring opening and the production of heavy metal orthoesters.
Uses of Potassium Tert-Butoxide (KOtBu)
As a Strong Base in Organic Synthesis.
Potassium tert-butoxide is commonly employed as a solid non-nucleophilic basic in chemical synthesis. Its principal application is in deprotonation reactions, where it aids in forming carbanions, which are important intermediates in various chemical processes. For example, potassium tert-butoxide is extremely useful in synthesising enolates due to its strong basicity and ability to deprotonate weakly acidic hydrogen atoms.
- Elimination Reactions
Another critical application of potassium t-butoxide is in the elimination process, namely the E2 mechanism. These reactions help remove a proton and a leaving group from nearby carbon atoms, producing alkenes. This feature is widely used in synthesising olefins, which are essential intermediates in the manufacture of polymers.
- As a catalyst in many reactions
Potassium tert-butoxide also catalyses several chemical processes, such as the Claisen condensation, Michael addition, and Wittig reaction. These reactions are essential for forming carbon-carbon bonds and are frequently employed in synthesising complex organic compounds.
In Pharmaceutical Manufacturing
In the pharmaceutical business, potassium tert-butoxide (potassium tert-butanolate) is used to produce active pharmaceutical ingredients (APIs). Its capacity to precisely trigger specific chemical reactions makes it extremely useful in medication development. For example, it is utilised in synthesising antiviral and anticancer drugs, where precise control over the reaction conditions is essential.
Agrochemical Production
Key reagent for the synthesis of herbicides, fungicides, and pesticides.
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Why Purchase Potassium Tert-Butoxide (KOtBu) from Gneebio?
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